| Autor: |
Anis Karuniawati, Ayodhia Pitaloka Pasaribu, Gilbert Lazarus, Vera Irawany, Dwi Utomo Nusantara, Robert Sinto, Suwarti, Maulana Jamil Nasution, Ferawati, Muhammad Riza Lubis, Eka Nurfitri, Mutiara Mutiara, Hasanul Arifin, Hely Hely, Pramaisshela Arinda D. Putri, Ariel Pradipta, Anindya Pradipta Susanto, Meutia Ayuputeri Kumaheri, Bonifacius, Yacobus Da Costa, Claus Bogh, Dodi Safari, Kartini Lidia, Hermi Indita Malewa, Nunung Nuraeni, Sabighoh Zanjabila, Mutia Rahardjani, Fitri Agustia Dewi, Fitria Wulandari, Decy Subekti, Henry Surendra, J. Kevin Baird, Anuraj H. Shankar, Raph L. Hamers |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
The Lancet Regional Health - Southeast Asia, Vol 22, Iss , Pp 100348- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2772-3682 |
| DOI: |
10.1016/j.lansea.2023.100348 |
| Popis: |
Summary: Background: Limited data exist from southeast Asia on the impact of SARS-CoV-2 variants and inactivated vaccines on disease severity and death among patients hospitalised with COVID-19. Methods: A multicentre hospital-based prospective cohort was enrolled from September 2020 through January 2023, spanning pre-delta, delta, and omicron periods. The participant hospitals were conveniently sampled based on existing collaborations, site willingness and available study resources, and included six urban and two rural general hospitals from East Nusa Tenggara, Jakarta, and North Sumatra provinces. Factors associated with severe disease and day-28 mortality were examined using logistic and Cox regression. Findings: Among 822 participants, the age-adjusted percentage of severe disease was 26.8% (95% CI 22.7–30.9) for pre-delta, 50.1% (44.0–56.2) for delta, and 15.2% (9.7–20.7) for omicron. The odds of severe disease were 64% (18–84%) lower for omicron than delta (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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