Drug-Eluting Nasal Implants: Formulation, Characterization, Clinical Applications and Challenges

Autor: Ankit Parikh, Utkarshini Anand, Malachy C. Ugwu, Tiam Feridooni, Emad Massoud, Remigius U. Agu
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Pharmaceutics, Vol 6, Iss 2, Pp 249-267 (2014)
Druh dokumentu: article
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics6020249
Popis: Chronic inflammation and infection of the nasal sinuses, also referred to as Chronic Rhinosinusitis (CRS), severely affects patients’ quality of life. Adhesions, ostial stenosis, infection and inflammation relapses complicate chronic sinusitis treatment strategies. Drug-eluting stents, packings or implants have been suggested as reasonable alternatives for addressing these concerns. This article reviewed potential drug candidates for nasal implants, formulation methods/optimization and characterization methods. Clinical applications and important considerations were also addressed. Clinically-approved implants (Propel™ implant, the Relieva stratus™ MicroFlow spacer, and the Sinu-Foam™ spacer) for CRS treatment was an important focus. The advantages and limitations, as well as future considerations, challenges and the need for additional research in the field of nasal drug implant development, were discussed.
Databáze: Directory of Open Access Journals