Impact of maternal neuraxial labor analgesia exposure on offspring's neurodevelopment: A longitudinal prospective cohort study with propensity score matching

Autor: Chun-Mei Deng, Ting Ding, Zhi-Hua Liu, Shu-Ting He, Jia-Hui Ma, Ming-Jun Xu, Lei Wang, Ming Li, Wei-Lan Liang, Xue-Ying Li, Daqing Ma, Dong-Xin Wang
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Frontiers in Public Health, Vol 10 (2022)
Druh dokumentu: article
ISSN: 2296-2565
DOI: 10.3389/fpubh.2022.831538
Popis: BackgroundNeuraxial analgesia is widely used to relieve labor pain; its effects on long-term neurodevelopment of offspring remain unclear. This study was designed to investigate the influence of maternal neuraxial labor analgesia on offspring mental development.MethodsThis was a predefined secondary analysis of a 2-year prospective longitudinal study. Nulliparous women with single-term cephalic pregnancy preparing for vaginal delivery self-selected neuraxial analgesia or not during labor. Mothers and their offspring were followed up 2 years later. children's mental development was assessed with the bayley scales of infant development. A multivariable logistic model was used to identify factors associated with below-average mental development (Mental Development Index
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