| Autor: |
Fermér Maria, Landegren Ulf, Kindmark Andreas, Syvänen Ann-Christine, Melhus Håkan, Magnusson Cecilia, Humphreys Keith, Lovmar Lovisa, Wedrén Sara, Stiger Fredrik, Persson Ingemar, Baron John, Weiderpass Elisabete |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
BMC Cancer, Vol 8, Iss 1, p 322 (2008) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2407 |
| DOI: |
10.1186/1471-2407-8-322 |
| Popis: |
Abstract Background Estrogen is an established endometrial carcinogen. One of the most important mediators of estrogenic action is the estrogen receptor alpha. We have investigated whether polymorphic variation in the estrogen receptor alpha gene (ESR1) is associated with endometrial cancer risk. Methods In 702 cases with invasive endometrial cancer and 1563 controls, we genotyped five markers in ESR1 and used logistic regression models to estimate odds ratios (OR) and 95 percent confidence intervals (CI). Results We found an association between rs2234670, rs2234693, as well as rs9340799, markers in strong linkage disequilibrium (LD), and endometrial cancer risk. The association with rs9340799 was the strongest, OR 0.75 (CI 0.60–0.93) for heterozygous and OR 0.53 (CI 0.37–0.77) for homozygous rare compared to those homozygous for the most common allele. Haplotype models did not fit better to the data than single marker models. Conclusion We found that intronic variation in ESR1 was associated with endometrial cancer risk. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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