Paediatric norms for photopic electroretinogram testing based on a large cohort of Chinese preschool children

Autor: Henry Ho-lung Chan, Sonia Seen-hang Chan, Kai Yip Choi
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMJ Open Ophthalmology, Vol 9, Iss 1 (2024)
Druh dokumentu: article
ISSN: 2397-3269
DOI: 10.1136/bmjophth-2023-001393
Popis: Objective Full-field electroretinogram (ffERG) is an objective test to determine the electroretinal activities in response to light stimulation for investigating retinal physiology and diagnosing retinal diseases. This study aimed to establish a reference data set of photopic electroretinogram (ERG) of Chinese preschool children in Hong Kong to facilitate clinical and research studies.Methods and analysis Preschool children aged 3–7 years with normal vision were recruited from local kindergartens. Eye examinations, including cycloplegic spherical equivalent refraction (SER), axial length (AL) and keratometry (K) measurements, were performed. ffERGs of the International Society for Clinical Electrophysiology of Vision (ISCEV) standard photopic flash and 30-Hz flicker protocols were measured using RETeval with Sensor Strip skin electrodes. ERG waveform characteristics were extracted, and relationships between ERG, age, SER, AL and K were evaluated.Results A total of 479 children completed the measurements (mean age: 5.0±0.9 years, 45.5% female). Mean, 95% CIs, 5th–95th percentile range of the ERG parameters were reported. Age was positively associated with amplitudes of b-wave and 30-Hz flicker (p
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