Uniting RNAi Technology and Conservation Biocontrol to Promote Global Food Security and Agrobiodiversity

Autor: Jonathan Willow, Samantha M. Cook, Eve Veromann, Guy Smagghe
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Druh dokumentu: article
ISSN: 2296-4185
DOI: 10.3389/fbioe.2022.871651
Popis: Habitat loss and fragmentation, and the effects of pesticides, contribute to biodiversity losses and unsustainable food production. Given the United Nation’s (UN’s) declaration of this decade as the UN Decade on Ecosystem Restoration, we advocate combining conservation biocontrol-enhancing practices with the use of RNA interference (RNAi) pesticide technology, the latter demonstrating remarkable target-specificity via double-stranded (ds)RNA’s sequence-specific mode of action. This specificity makes dsRNA a biosafe candidate for integration into the global conservation initiative. Our interdisciplinary perspective conforms to the UN’s declaration, and is facilitated by the Earth BioGenome Project, an effort valuable to RNAi development given its utility in providing whole-genome sequences, allowing identification of genetic targets in crop pests, and potentially relevant sequences in non-target organisms. Interdisciplinary studies bringing together biocontrol-enhancing techniques and RNAi are needed, and should be examined for various crop‒pest systems to address this global problem.
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