Side Effects of Stem Cell Transplant Mimicking Symptoms of Known Amyloidosis

Autor: Gabriel Heering, Zilan Lin, Michael Rosman, Nao Hara, Fouzia Shakil, Dimitrios Georgostathis
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Case Reports in Gastroenterology, Vol 18, Iss 1, Pp 273-278 (2024)
Druh dokumentu: article
ISSN: 1662-0631
DOI: 10.1159/000538947
Popis: Introduction: AL amyloidosis can involve the gastrointestinal (GI) tract in a sporadic manner, affecting certain anatomical areas while sparing others. Case Presentation: Our patient with AL amyloidosis and confirmed colonic involvement was found to have new odynophagia, GI bleeding, and imaging findings that might suggest AL amyloidosis. However, negative pathology results from esophageal biopsies suggested the patient’s new ulcerations were more likely a side effect of her autologous stem cell transplant (SCT) and chemotherapy meant to target amyloidosis, as opposed to an effect of amyloid infiltration itself. Conclusion: GI involvement of amyloidosis requires a high degree of clinical suspicion and should be considered in patients with systemic diseases affecting the kidney, heart, and GI tract; however, when satisfactory biopsies obtained from endoscopy results are negative, other causes should be considered.
Databáze: Directory of Open Access Journals
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