| Autor: |
Vahid Kheirollahi, Roxana M. Wasnick, Valentina Biasin, Ana Ivonne Vazquez-Armendariz, Xuran Chu, Alena Moiseenko, Astrid Weiss, Jochen Wilhelm, Jin-San Zhang, Grazyna Kwapiszewska, Susanne Herold, Ralph T. Schermuly, Bernard Mari, Xiaokun Li, Werner Seeger, Andreas Günther, Saverio Bellusci, Elie El Agha |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-019-10839-0 |
| Popis: |
Idiopathic pulmonary fibrosis is associated with myofibroblast activation in the lungs and metabolic alterations. Here, the authors show that the antidiabetic drug metformin has antifibrotic effects in human-derived samples and mouse models, by modulating a number of metabolic pathways to induce lipogenic transdifferentiation of myofibroblasts. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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