| Autor: |
Kamil Özdil, Zuhal Çalışkan, Nurşen Keleş, Oğuzhan Öztürk, Ahmet Selami Tekin, Resul Kahraman, Levent Doğanay, Kenan Demircioğlu, Yusuf Yılmaz, Mustafa Çalışkan |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
İstanbul Kuzey Klinikleri, Vol 4, Iss 1, Pp 4-12 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2148-4902 |
| DOI: |
10.14744/nci.2017.74508 |
| Popis: |
INTRODUCTION[|]Inflammatory bowel diseases (IBD) consist of a number of chronic inflammatory diseases. Inflammatory process is known to be involved in all stages of atherosclerosis. Early atherosclerosis is reflected by increased levels of carotid artery intima media thickness (c-IMT) and high-sensitivity C-reactive protein (hs-CRP). Epicardial fat thickness (EFT) strongly influences both the formation and progression of atherosclerosis. Recent studies have demonstrated a relationship between c-IMT and hs-CRP levels and the risk of atherosclerosis in patients with IBD. However, no study has yet compared EFT between patients with IBD and the general healthy population. Hence, this study was designed to further evaluate whether patients with IBD have higher EFT values with increased c-IMT and hs-CRP levels compared to those in the healthy population.[¤]METHODS[|]A total of 110 patients with IBD and 105 healthy volunteers were enrolled into this study. EFT was evaluated by transthoracic echocardiography. c-IMT levels were measured using an ultrasound scanner with a linear probe. The plasma levels of hs-CRP were measured using a highly sensitive sandwich ELISA technique.[¤]RESULTS[|]The hs-CRP and c-IMT levels of patients with IBD were significantly higher than those of the control group. The EFT values of patients with IBD were significantly higher than those of the control group (0.54+-0.13 vs. 0.49+-0.09, p=0.002).[¤]DISCUSSION AND CONCLUSION[|]Echocardiographic EFT measurements of patients with IBD were significantly higher than those of the normal population, which may be associated with an increased subclinical atherosclerosis risk in these patients.[¤] |
| Databáze: |
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| Externí odkaz: |
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