Association of human papillomavirus and Chlamydia trachomatis with intraepithelial alterations in cervix samples
| Autor: | Denise Wohlmeister, Débora Renz Barreto Vianna, Virgínia Etges Helfer, Fabrícia Gimenes, Marcia Edilaine Lopes Consolaro, Regina Bones Barcellos, Maria Lucia Rossetti, Luciane Noal Calil, Andréia Buffon, Diogo André Pilger |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Memorias do Instituto Oswaldo Cruz, Vol 111, Iss 2, Pp 106-113 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1678-8060 0074-0276 |
| DOI: | 10.1590/0074-02760150330 |
| Popis: | The influence of different infectious agents and their association with human papillomavirus (HPV) in cervical carcinogenesis have not been completely elucidated. This study describes the association between cytological changes in cervical epithelium and the detection of the most relevant aetiological agents of sexually transmitted diseases. Samples collected from 169 patients were evaluated by conventional cytology followed by molecular analysis to detect HPV DNA, Chlamydia trachomatis, herpes simplex virus 1 and 2,Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis, andTreponema pallidum, besides genotyping for most common high-risk HPV. An association between cytological lesions and different behavioural habits such as smoking and sedentariness was observed. Intraepithelial lesions were also associated with HPV and C. trachomatis detection. An association was also found between both simple and multiple genotype infection and cytological changes. The investigation of HPV and C. trachomatisproved its importance and may be considered in the future for including in screening programs, since these factors are linked to the early diagnosis of patients with precursor lesions of cervical cancer. |
| Databáze: | Directory of Open Access Journals |
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