Studies of Anti-Viral Activity of Chemically Synthesized Compounds against Orthopoxviruses in vitro
| Autor: | A. S. Kabanov, Al. A. Sergeev, L. E. Bulychev, N. I. Bormotov, L. N. Shishkina, Ar. A. Sergeev, S. A. Bodnev, M. O. Skarnovich, A. R. Shevtsov, B. A. Selivanov, A. Ya. Tikhonov, A. P. Agafonov, A. N. Sergeev |
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| Jazyk: | ruština |
| Rok vydání: | 2013 |
| Předmět: |
ортопоксвирусы
вирус оспы обезьян вирус натуральной оспы культура клеток vero токсичность противовирусная активность конденсированные производные пирролидин-2 5-диона orthopoxviruses monkeypox virus variola virus vero cell culture toxicity anti-viral activity condensed derivatives of pyrrolidine-25-dion Infectious and parasitic diseases RC109-216 |
| Zdroj: | Проблемы особо опасных инфекций, Vol 0, Iss 2, Pp 54-59 (2013) |
| Druh dokumentu: | article |
| ISSN: | 0370-1069 2658-719X |
| DOI: | 10.21055/0370-1069-2013-2-54-59 |
| Popis: | for ST-246 and NIOC-14 is within the range of 0,001-0,004 µg/ml, and IS for both of them is > 100000. In addition, ST-246 and NIOC-14 chemical compound efficacy, concentrated up to 0,0125; 0,025 and 0,05 µg/ml, in accordance with prophylactic charts describing an impact on ectromelia virus (EV) infectivity in vitro, is consequently 0,6; 3 and 1 lg higher than in case of compound application after an hour of Vero cells infection with EV. |
| Databáze: | Directory of Open Access Journals |
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