Clostridioides difficile ribotype distribution in a large teaching hospital in Serbia

Autor: Miloš Korać, Maja Rupnik, Nataša Nikolić, Milica Jovanović, Tanja Tošić, Jovan Malinić, Nikola Mitrović, Marko Marković, Ankica Vujović, Sanja Peruničić, Ksenija Bojović, Vladimir Djordjević, Aleksandra Barać, Ivana Milošević
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Gut Pathogens, Vol 12, Iss 1, Pp 1-6 (2020)
Druh dokumentu: article
ISSN: 1757-4749
DOI: 10.1186/s13099-020-00364-7
Popis: Abstract Background The global epidemic of nosocomial diarrhea caused by Clostridioides (Clostridium) difficile started in 2000, with high mortality rates and emergence of a new hypervirulent strain NAP1/BI/027. The aim of this study was to assess the presence of ribotype 027 and other C. difficile ribotypes in a Serbian University Hospital, compare the temporal variability of ribotypes 3 years apart, as well as to compare clinical, demographic and laboratory characteristics and disease outcome among patients infected with 027 and non-027 ribotype. This was a prospective observational cohort study addressing 4-month intervals during 2014/2015 and 2017/2018. Results Ribotyping was performed in 64 non-duplicate C. difficile strains. Ribotype 027 was the most prevalent, and was detected in 53 (82.8%) patients (43/45 and 10/19 patients in 2014–2015 and 2017/2018, respectively). Other detected ribotypes were 001/072 in 4 (6.3%), 002 in 4 (6.3%), 014/020 in 2 (3.1%) and 176 in 1 (1.5%) patient. The percentage of the patients infected with ribotype 027 significantly decreased during the 3-year period, from 95.6 to 52.6% (p
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