| Autor: |
Dylan J. Martini, Meredith R. Kline, Yuan Liu, Julie M. Shabto, Bradley C. Carthon, Greta Anne Russler, Lauren Yantorni, Emilie Elise Hitron, Sarah Caulfield, Jamie M. Goldman, Wayne B. Harris, Omer Kucuk, Viraj A Master, Mehmet Asim Bilen |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Cancer Treatment and Research Communications, Vol 28, Iss , Pp 100393- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2468-2942 |
| DOI: |
10.1016/j.ctarc.2021.100393 |
| Popis: |
Background: Cabozantinib is an effective treatment for metastatic renal cell carcinoma (mRCC). The international mRCC database consortium (IMDC) criteria is the gold standard for risk stratification in mRCC. We created a risk scoring system specific for mRCC patients treated with cabozantinib. Methods: We conducted a retrospective review of 87 patients with mRCC treated with cabozantinib at Winship Cancer Institute from 2015 to 2019. Overall survival (OS) and progression free survival (PFS) were used to measure clinical outcomes. Upon variable selection in multivariable analysis (MVA), elevated baseline monocyte-to-lymphocyte ratio (MLR), sarcomatoid histologic component, ECOG PS > 1, and absence of bone metastases were each assigned 1 point. A three-group risk scoring system was then created: low (score=0–1), intermediate (score=2), and high risk (score=3–4). The Cox proportional hazard model and Kaplan-Meier method were used for survival analyses. Results: The median age was 62 years-old and the majority were males (71%) with clear-cell RCC (75%). Most (67%) received at least 1 prior line of systemic therapy. High risk and intermediate risk pts had significantly shorter OS (high risk HR: 13.84, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect