Correlation between circulating advanced glycation end products and thioredoxin-interacting protein levels and renal fat content in type 2 diabetes mellitus patients

Autor:	Yulin Hua, Zaifei Yin, Mingming Li, Hong Sun, Bimin Shi
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Renal fat fraction Advanced glycation end products Soluble receptor for advanced glycation end products Thioredoxin-interacting protein Type 2 diabetes mellitus Nutritional diseases. Deficiency diseases RC620-627
Zdroj:	Diabetology & Metabolic Syndrome, Vol 16, Iss 1, Pp 1-9 (2024)
Druh dokumentu:	article
ISSN:	1758-5996
DOI:	10.1186/s13098-024-01361-5
Popis:	Abstract Background This study sought to explore the clinical relevance of the associations of serum levels of advanced glycation end products (AGEs), soluble receptor for AGEs (sRAGE), and thioredoxin-interacting protein (TXNIP) with the renal fat fraction (RFF) in individuals with type 2 diabetes mellitus (T2DM). Methods A total of 133 patients with T2DM were enrolled in the study. RFF, which represents the renal fat level, was determined utilizing Dixon magnetic resonance imaging (MRI). Serum levels of AGEs, sRAGE, TXNIP, and other biochemical parameters were measured in patients who fasted. Results RFF in T2DM patients was positively correlated with the fasting levels of C-peptide (CP), triglycerides (TG), AGEs, TXNIP, and sRAGE (P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/883542c451b54c9dbac4297a688f4e13 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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