The role of thymus and activation-regulated chemokine in diagnostics of atopic dermatitis at children

Autor: V.O. Dytiatkovskyi, O.E. Abaturov, O.O. Alifirenko, I.A. Filatova, S.M. Taran
Jazyk: English<br />Ukrainian
Rok vydání: 2021
Předmět:
Zdroj: Zdorovʹe Rebenka, Vol 16, Iss 2, Pp 122-127 (2021)
Druh dokumentu: article
ISSN: 2224-0551
2307-1168
DOI: 10.22141/2224-0551.16.2.2021.229876
Popis: Background. At present, total immunoglobulin E, which has been used as a basic biomarker of atopy for several decades, in most cases does not reflect the severity of allergic inflammation in the skin in children suffering from atopic dermatitis (AD). Therefore, there is a need for new serum biomarkers that would allow to accurately diagnose the severity degree, control the course of AD and prevent its transformation into phenotypes in combination with other atopic diseases (AtD). In the past two decades, a new biomarker of the inflammation severity degree in the skin within AD — thymus- and activation-regulated chemokine (TARC/CCL17), associated with T-lymphocytes type 2 has been actively studied. The purpose of the study was to determine the associations of serum concentrations of TARC/CCL17 with the AD in children: age, severity, and AD phenotypes — isolated and combined with comorbid AtD. Materials and methods. The basic group comprised 39 children with atopic dermatitis aged 3–6, 7–11, and 12–18 years old. The phenotypes of the basic group were AD isolated and combined with comorbid AtD — seasonal allergic rhinitis/rhinoconjunctivitis, and/or perennial allergic rhinitis, and/or bronchial asthma. The control group comprised 47 children with gastrointestinal pathology without clinical signs of atopy. The severity of AD in children of the basic group was determined using the scoring atopic dermatitis index (SCORAD). Results. Significant direct associations of TARC/CCL17 with the AD severity and the SCORAD index, which is a clinical marker of AD severity, were determined. A reverse association was found between TARC/CCL17 and the age of patients in both the basic and control groups. Also, significant associations were found with the patients’ age increase, with the development of the AD phenotype combined with comorbid AtD and male gender (reverse significant association between age and female gender). Conclusions. TARC/CCL17 is significantly associated with the severity degree increase in patients with AD of all the phenotypes — isolated and combined with comorbid AtD. With the age increase, the level of TARC/CCL17 decreases, AD has a trend to progress into phenotype combined with other AtDs, and the incidence increases among male patients. The use of TARC/CCL17 in the diagnostic process of atopic dermatitis in children will provide more personalized control and prevention of progression of the disease into phenotypes combined with other atopic diseases.
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