Interaction between sex and neurofilament light chain on brain structure and clinical severity in Huntington’s disease

Autor:	Frederic Sampedro, Saul Martinez‐Horta, Jesús Pérez‐Pérez, Rocio Perez‐Gonzalez, Andrea Horta‐Barba, Antonia Campolongo, Ignacio Aracil‐Bolaños, Beatriz Gomez‐Anson, Jaume Kulisevsky
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Zdroj:	Annals of Clinical and Translational Neurology, Vol 8, Iss 12, Pp 2309-2313 (2021)
Druh dokumentu:	article
ISSN:	2328-9503
DOI:	10.1002/acn3.51460
Popis:	Abstract Female Huntington’s disease (HD) patients have consistently shown a faster clinical worsening than male, but the underlying mechanisms responsible for this observation remain unknown. Here, we describe how sex modifies the impact of neurodegeneration on brain atrophy and clinical severity in HD. Cerebrospinal fluid neurofilament light chain (NfL) levels were used as a biological measure of neurodegeneration, and brain atrophy was assessed by structural magnetic resonance imaging. We found that larger NfL values in women reflect higher brain atrophy and clinical severity than in men (p
Databáze:	Directory of Open Access Journals
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