Dysbiosis by Eradication of Helicobacter pylori Infection Associated with Follicular Gastropathy and Pangastropathy
| Autor: | Uriel Gomez-Ramirez, Carolina G. Nolasco-Romero, Araceli Contreras-Rodríguez, Gerardo Zuñiga, Sandra Mendoza-Elizalde, Francisco-Javier Prado-Galbarro, Fernando Pérez Aguilar, Jonatan Elihu Pedraza Tinoco, Pedro Valencia-Mayoral, Norma Velázquez-Guadarrama |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Microorganisms, Vol 11, Iss 11, p 2748 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2076-2607 33084114 |
| DOI: | 10.3390/microorganisms11112748 |
| Popis: | Dysbiosis plays an important role in the development of bacterial infections in the gastric mucosa, particularly Helicobacter pylori. The international guidelines for the treatment of H. pylori infections suggest standard triple therapy (STT). Nevertheless, because of the increasing resistance rates to clarithromycin, metronidazole has been widely considered in several countries. Unfortunately, the non-justified administration of antibiotics induces dysbiosis in the target organ. We characterized the gastric microbiota of patients diagnosed with follicular gastropathy and pangastropathy attributed to H. pylori infection, before and after the administration of STT with metronidazole. Dominant relative abundances of Cutibacterium were observed in pre-treatment patients, whereas H. pylori was observed at Cutibacterium acnes and H. pylori with gastric infectious diseases was also evaluated using quantitative real-time polymerase chain reaction. The dominance of C. acnes over H. pylori was observed in gastritis, gastropathies, and non-significant histological alterations. None of the microorganisms were detected in the intestinal metaplasia. Post-treatment alterations revealed an increase in the relative abundances of Staphylococcus, Pseudomonas, and Klebsiella. Non-H. pylori gastrointestinal bacteria can be associated with the initiation and development of gastric diseases, such as pathobiont C. acnes. |
| Databáze: | Directory of Open Access Journals |
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