| Autor: |
Fabiola Del Carlo Bernardi, Eduardo Algranti, Marisa Dolhnikoff, Clóvis Antônio Lopes Pinto, Ivanir Martins de Oliveira, Ester Nei Aparecida Martins Coletta, Eduardo Caetano Albino da Silva, Adauto José Ferreira Nunes, Donaldo Botelho Veneziano, Carolina Terra de Moraes Luizaga, Ricardo Luiz Lorenzi, Diego Rodrigues Mendonça e Silva, Thais Mauad |
| Jazyk: |
English<br />Portuguese |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Jornal Brasileiro de Pneumologia, Vol 50, Iss 2 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1806-3756 |
| DOI: |
10.36416/1806-3756/e20230343 |
| Popis: |
ABSTRACT Objective: To review the pathological diagnosis of possible cases and/or hidden cases of malignant mesothelioma (MM) between 2000 and 2012 using the Hospital-Based Cancer Registry database in the state of São Paulo, Brazil. Methods: Possible cases were retrieved by assessing the database. Inclusion criteria were being older than 30 years of age and having ICD-O-3 topography and morphology codes related to MM. A board of expert pathologists reviewed the pathology reports and requested paraffin blocks in cases that demanded revision. After staining with calretinin, D2-40, WT-1 (as positive MM markers) and Ber-EP4 and MOC31 (as negative MM markers), cases were divided and studied independently by a pair of pathologists to confirm or discard the diagnosis of MM. Results: Our sample comprised 482 cases from 25 hospitals, and 130 needed further histological revision. We received 73 paraffin blocks with adequate material. After board analysis, there were 9 cases with a definitive diagnosis of MM, improving the diagnostic rate in 12%. Two cases of previously diagnosed MM were discarded by review. Conclusions: Our results confirm that part of MM underdiagnosis and underreporting in Brazil is due to incomplete or mistaken pathological diagnosis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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