| Autor: |
Kirsten E. Zeuner, Arne Knutzen, Oliver Granert, Simone Sablowsky, Julia Götz, Stephan Wolff, Olav Jansen, Dirk Dressler, Susanne A. Schneider, Christine Klein, Günther Deuschl, Thilo van Eimeren, Karsten Witt |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
NeuroImage: Clinical, Vol 10, Iss C, Pp 63-70 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
2213-1582 |
| DOI: |
10.1016/j.nicl.2015.11.006 |
| Popis: |
Previous receptor binding studies suggest dopamine function is altered in the basal ganglia circuitry in task-specific dystonia, a condition characterized by contraction of agonist and antagonist muscles while performing specific tasks. Dopamine plays a role in reward-based learning. Using fMRI, this study compared 31 right-handed writer's cramp patients to 35 controls in reward-based learning of a probabilistic reversal-learning task. All subjects chose between two stimuli and indicated their response with their left or right index finger. One stimulus response was rewarded 80%, the other 20%. After contingencies reversal, the second stimulus response was rewarded in 80%. We further linked the DRD2/ANKK1-TaqIa polymorphism, which is associated with 30% reduction of the striatal dopamine receptor density with reward-based learning and assumed impaired reversal learning in A+ subjects. Feedback learning in patients was normal. Blood-oxygen level dependent (BOLD) signal in controls increased with negative feedback in the insula, rostral cingulate cortex, middle frontal gyrus and parietal cortex (pFWE |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
