Gut microbiota-host lipid crosstalk in Alzheimer’s disease: implications for disease progression and therapeutics

Autor:	Ya-Xi Luo, Ling-Ling Yang, Xiu-Qing Yao
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Gut microbiota Lipid metabolism Alzheimer’s disease Cholesterol SCFAs LPS Neurology. Diseases of the nervous system RC346-429 Geriatrics RC952-954.6
Zdroj:	Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-25 (2024)
Druh dokumentu:	article
ISSN:	1750-1326 67447104
DOI:	10.1186/s13024-024-00720-0
Popis:	Abstract Trillions of intestinal bacteria in the human body undergo dynamic transformations in response to physiological and pathological changes. Alterations in their composition and metabolites collectively contribute to the progression of Alzheimer’s disease. The role of gut microbiota in Alzheimer’s disease is diverse and complex, evidence suggests lipid metabolism may be one of the potential pathways. However, the mechanisms that gut microbiota mediate lipid metabolism in Alzheimer’s disease pathology remain unclear, necessitating further investigation for clarification. This review highlights the current understanding of how gut microbiota disrupts lipid metabolism and discusses the implications of these discoveries in guiding strategies for the prevention or treatment of Alzheimer’s disease based on existing data.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/e833a67447104e73aa7707891cbd447f Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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