| Autor: |
Yongqin Li, Yuxin Chen, Shaoshuai Mao, Ravinder Kaundal, Zhengyu Jing, Qin Chen, Xinxin Wang, Jing Xia, Dahai Liu, Jianlong Sun, Haopeng Wang, Tian Chi |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-020-15836-2 |
| Popis: |
Mutations that affect Treg cell function can cause lethal autoimmunity, but whether correcting these mutations can reverse established disease is unclear. Here, the authors correct Treg cell-specific Brg1 mutation in a minor fraction of Treg cells, which supercharges these cells to rescue mice from otherwise fatal IPEX-like autoimmunity. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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