Metastatic Melanoma Treatment with Pembrolizumab after Hypersensitivity Reaction to Nivolumab: A Case Report

Autor:	Alyssa R. Cruse, Alexa J. Basilio, David H. Lawson
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	hypersensitivity programmed death protein-1 checkpoint inhibitors case report Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Case Reports in Oncology, Vol 16, Iss 1, Pp 1232-1236 (2023)
Druh dokumentu:	article
ISSN:	1662-6575
DOI:	10.1159/000534023
Popis:	Programmed death protein-1 (PD-1) checkpoint inhibitors such as pembrolizumab and nivolumab are cornerstones to metastatic melanoma treatment, and they are often considered to be pharmacologically similar and interchangeable when it comes to designing chemotherapy regimens. In this case report, we describe a patient who had consistent immune reactions to nivolumab infusion but was able to tolerate pembrolizumab, without any reactions, when given hydrocortisone premedication. This case demonstrates a successful transition from one PD-1 checkpoint inhibitor to another with resolution of infusion-related reactions in a patient undergoing treatment for metastatic melanoma.
Databáze:	Directory of Open Access Journals
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