The association between serum hepcidin-25 level and subclinical atherosclerosis in peritoneal dialysis patients

Autor: Bülent Erdoğan, Barış Eser, Özlem Yayar, Mehmet Deniz Aylı
Jazyk: English<br />Turkish
Rok vydání: 2018
Předmět:
Zdroj: Türk Kardiyoloji Derneği Arşivi, Vol 46, Iss 2, Pp 121-128 (2018)
Druh dokumentu: article
ISSN: 1016-5169
DOI: 10.5543/tkda.2017.17666
Popis: Objective: Recently, the role of hepcidin as a cardiovascular marker in the chronic kidney disease (CKD) population has gained interest. The aim of this study was to investigate the relationship between serum hepcidin-25, inflammation, iron parameters, and carotid intima-media thickness (CIMT) in peritoneal dialysis (PD) patients. Methods: A total of 58 patients (30 male, 51.3%; mean age: 46.8+-13.6 years; mean dialysis duration: 69.2+-39.1 months) were included in this cross-sectional study. Clinical and routine laboratory data were recorded and the CIMT and hepcidin values were determined. The study population was divided into 2 groups according to the median hepcidin value of 60 ng/mL. Correlation analysis and logistic regression analysis were performed to determine the relationship between the hepcidin level and other parameters. Results: Age (p=0.003), systolic blood pressure (p=0.039), body mass index (p=0.031), glucose (p=0.028) level, C-reactive protein (CRP) level (p
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