| Autor: |
Anna Bergström, Hans Hägglund, Anders Berglund, Gunnar Nilsson, Mats Lambe |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Acta Oncologica, Vol 63, Iss 1 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1651-226X |
| DOI: |
10.2340/1651-226X.2024.31406 |
| Popis: |
Background: Mastocytosis is a disease characterized by accumulation of aberrant mast cells and mediator-related symptoms and is divided into systemic mastocytosis (SM) and cutaneous mastocytosis (CM). The epidemiology of mastocytosis remains incompletely understood. Objective: To estimate the incidence, prevalence, overall survival (OS) and burden of comorbidities in adult mastocytosis patients identified in Swedish population-based registries. Methods: Individuals (≥ 20 years of age) with a mastocytosis diagnosis in the National Patient Register (NPR) and/or the Swedish Cancer Register (SCR) between 2001 and 2018, were identified. In a matched cohort design, for each case five randomly selected mastocytosis-free comparators matched on age, sex, and county of residence were chosen from the Population Register. The Kaplan-Meier method was used to compare OS between individuals with mastocytosis and comparators. Information on concomitant disease at baseline was assessed by use of the Charlson Comorbidity Index (CCI). Results: We identified 2,040 adults with a mastocytosis diagnosis yielding an annual incidence of 1.56 per 100,000 (95% CI 1.29–1.87) and a prevalence of 23.9 per 100,000 (95% CI 22.8–25.0). The comorbidity burden was higher, and the OS lower, in patients with mastocytosis compared to comparators. Interpretation: We found a higher incidence and prevalence of mastocytosis compared to assessments in other settings and confirmed that the prognosis generally is favorable. Of special note was evidence of a higher comorbidity burden in mastocytosis patients compared to the background population. Limitations: Underreporting and inconsistencies in the use of diagnostic codes. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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