Identification of key genes and pathways in syphilis combined with diabetes: a bioinformatics study

Autor:	Wei Li, Chunyi Luo, Xiaoping Xie, Yongjian Xiao, Feijun Zhao, Jialun Cai, Xiangping Zhou, Tiebing Zeng, Bo Fu, Yimou Wu, Xinhua Xiao, Shuangquan Liu
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Treponema pallidum Syphilis Diabetes mellitus Bioinformatics Biotechnology TP248.13-248.65 Microbiology QR1-502
Zdroj:	AMB Express, Vol 10, Iss 1, Pp 1-10 (2020)
Druh dokumentu:	article
ISSN:	2191-0855
DOI:	10.1186/s13568-020-01009-3
Popis:	Abstract We noticed that syphilis patients seem to be more susceptible to diabetes and the lesions often involve the kidneys, but the pathogenesis is not yet completely understood. In this study, microarray analysis was performed to investigate the dysregulated expressed genes (DEGs) in rabbit model of syphilis combined with diabetes. A total of 1045 genes were identified to be significantly differentially expressed, among which 571 were up-regulated and 474 were down-regulated (≥ 2.0fold, p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/811a2382e9cc45e19599fc21e6ace12e Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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