Effects of Repeated Administration of Dithiol Chelating Agent - Sodium 2,3-Dimercapto-1-propanesulphonate (DMPS) - On Biochemical and Haematological Parameters in Rabbits
| Autor: | Vladimír Geršl, Radomír Hrdina, Jaroslava Vávrová, Magdalena Holečková, Vladimír Palička, Jaroslava Voglová, Yvona Mazurová, Jiří Bajgar |
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| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: | |
| Zdroj: | Acta Medica, Vol 40, Iss 1, Pp 3-8 (1997) |
| Druh dokumentu: | article |
| ISSN: | 18059694 1211-4286 1805-9694 |
| DOI: | 10.14712/18059694.2020.34 |
| Popis: | The effects of weekly intravenously administered a dithiol chelating agent - sodium 2,3-dimercaptopropanesulphonate (DMPS) - in a single dose of 50 mg/kg/week for 10 weeks on biochemical and haematological parameters were studied in rabbits. DMPS was well tolerated, an increase in body weight was similar in the DMPS-treated and control animals. DMPS caused significant decrease in plasma calcium and vitamin E concentrations at the end of the experiment. No significant differences in haematological parameters between the DMPS and control groups were observed. A significant decrease in magnesium content in myocardial tissue was observed in the DMPS-treated rabbits. The above-mentioned biochemical changes should be taken into account in studies of possible chelating and radical scavenging effects of DMPS in various pathological conditions. |
| Databáze: | Directory of Open Access Journals |
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