Association of per- and polyfluoroalkyl substances (PFAS) with periodontitis: the mediating role of sex hormones

Autor: Yuxuan Wu, Yu Qiu, Yuying Wu, Husheng Li, Han Yang, Qingrong Deng, Baochang He, Fuhua Yan, Yanfen Li, Fa Chen
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Oral Health, Vol 24, Iss 1, Pp 1-11 (2024)
Druh dokumentu: article
ISSN: 1472-6831
DOI: 10.1186/s12903-024-03863-0
Popis: Abstract Objectives To investigate the association between serum per- and polyfluoroalkyl substances (PFAS) and periodontitis, and further explore the possible mediating role of sex hormones in this association. Methods We extracted data from National Health and Nutrition Examination Survey (NHANES) 2009–2014. Univariable and multivariable logistic regression models were performed to investigate the association between serum levels of seven PFASs and periodontitis. Bayesian kernel machine regression (BKMR) was conducted to assess the joint effect of PFASs in mixtures. Mediation analyses were used to explore the potential mediating role of sex hormones. Results Participants with periodontitis had higher concentrations of serum perfluorooctane sulfonate (PFOS) and perfluorononanoic acid (PFNA) than those without periodontitis (both P
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