| Autor: |
S. Girish, P. Sonje, A. Jagtap, P. Borle |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of Krishna Institute of Medical Sciences University, Vol 13, Iss 1, Pp 133-139 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2231-4261 |
| Popis: |
Background: The mechanistic relationship between the methylation process of the vitamin D gene and its impact on vitamin D levels and COVID-19 infection severity remains a subject of ongoing investigation. However, the lack of vaccines and targeted treatment in the initial phase of the pandemic had stimulated considerations regarding the potential use of vitamin D as a strategy for managing the disease. Vitamin D genes regulate vitamin D synthesis through epigenetic changes such as methylation, which affect various gene expressions. Aim and Objectives: The present study aimed to establish the relationship between vitamin D gene methylation in COVID-19 patients and vitamin D deficiency and the severity of COVID-19 symptoms. Material and Methods: Fifty RT-PCR confirmed SARS-CoV-2 patients were cross-sectionally evaluated, after ethical approval and informed consent, for severity of covid infection, serum levels of vitamin D along with other blood parameters and percentage of vitamin D gene methylation. ANOVA and correlation coefficient were used for statistical analyses with 'p' value |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
