TIPE2 knockdown exacerbates isoflurane-induced postoperative cognitive impairment in mice by inducing activation of STAT3 and NF-κB signaling pathways

Autor: Jian Rui, He Xin
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Translational Neuroscience, Vol 14, Iss 1, Pp 885-93 (2023)
Druh dokumentu: article
ISSN: 2081-6936
DOI: 10.1515/tnsci-2022-0282
Popis: Anesthetic exposure causes learning and memory impairment, the mechanisms of which remain unknown. It has been reported that tumor necrosis factor-α-inducer protein 8-like 2 (TIPE2) is a newly discovered immune negative regulator that is essential for maintaining immune homeostasis. This study aimed to examine the role of TIPE2 in isoflurane-induced postoperative cognitive decline (POCD).
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