Association of gastric lymphofollicular hyperplasia with Helicobacter‐like organisms in dogs

Autor: Tom Biénès, Rodolfo Oliveira Leal, Marina Domínguez‐Ruiz, Rodolfo Elvas De Carvalho, Nina Fernandes Rodrigues, Claire Dally, Jean‐Charles Husson, Kevin Le Boedec, Juan Hernandez
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Veterinary Internal Medicine, Vol 36, Iss 2, Pp 515-524 (2022)
Druh dokumentu: article
ISSN: 1939-1676
0891-6640
DOI: 10.1111/jvim.16387
Popis: Abstract Background The relationships among gastric lymphoid follicular hyperplasia (GLFH), Helicobacter‐like organisms (HLOs), and clinical signs have not been established in dogs. Objectives To evaluate the epidemiologic, clinical, endoscopic, and histopathologic findings associated with GLFH in dogs, and determine the association of GLFH with HLOs and the French Bulldog (FB) breed. Animals Two hundred eighty‐eight dogs that underwent gastroscopy between 2013 and 2016. Methods Retrospective, cross‐sectional study. Gastric biopsy samples were reviewed and scored for inflammation and HLOs. Dogs were divided into 3 groups: group 1 (63 FBs), group 2 (45 non‐FB brachycephalic dogs), and group 3 (180 nonbrachycephalic dogs). Variables were evaluated for their association with GLFH. Results Univariate analysis determined that intact males, young age, vomiting, gastroscopic findings (discoloration, hemorrhage, and ulcers), and histopathologic findings (gastric lamina propria lymphocytic infiltration and HLO score) were associated with GLFH (P ≤ .03). In the multivariate analysis, GLFH was associated with the HLO score (odds ratio [OR] > 5 for HLO scores 1‐2 and >15 for HLO score of 3; P 4; P = .01) but not with FB breed (P = .76) and age (P = .1). The HLO score was associated with younger age (P
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