Serum Levels of the Inflammatory Cytokines in Patients with Lumbar Radicular Pain Due to Disc Herniation
| Autor: | Bo Zu, Hong Pan, Xiao-Jun Zhang, Zong-Sheng Yin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Asian Spine Journal, Vol 10, Iss 5, Pp 843-849 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1976-1902 1976-7846 |
| DOI: | 10.4184/asj.2016.10.5.843 |
| Popis: | Study DesignCohort study.PurposeThis study primarily aimed to evaluate the serum levels of tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-4 in patients with lumbar radiculopathy 1 and 12 months after microdiscectomy.Overview of LiteratureLumbar radiculopathy is possibly caused by inflammatory changes in the nerve root. The intraneural application of pro-inflammatory cytokines induces behavioral signs associated with pain. Anti-inflammatory cytokine treatment effectively reduces hyperalgesia.MethodsThe role of TNF-α and IL-4 in long-lasting lumbar radiculopathy was addressed. A total of 262 patients were recruited from Anqing Hospital, Anhui Medical University. During inclusion at 1 and 12 months, serum concentrations of TNF-α and IL-4 were analyzed by enzyme-linked immunosorbent assay, and pain intensity was reported on a 0–10 cm visual analog scale (VAS).ResultsSixty six patients had VAS |
| Databáze: | Directory of Open Access Journals |
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