Menstrual problems are associated with elevated central venous pressure and predict adverse clinical events in women with congenital heart disease

Autor: Nao Konagai, Hideo Ohuchi, Kanae Noritake, Isao Shiraishi, Jun Yoshimatsu, Kenichi Kurosaki
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: International Journal of Cardiology Congenital Heart Disease, Vol 4, Iss , Pp 100198- (2021)
Druh dokumentu: article
ISSN: 2666-6685
DOI: 10.1016/j.ijcchd.2021.100198
Popis: Objectives: Despite the high prevalence of menstrual problems (MPs), their associations with hemodynamics and their prognostic value in women with congenital heart disease (WCHD) remain unknown. Methods: We retrospectively evaluated characteristics related to menstruation (age at menarche, menstrual cycle, and menstrual blood loss) in 143 consecutive WCHD, and investigated the associations of these characteristics with hemodynamics and prognosis. Results: A total of 132 WCHD were analyzed after excluding 11 patients in menopause. Diagnoses of abnormal onset of menarche (delayed menarche or primary amenorrhea) (AOM) and menstrual cycle disorders (MCDs) were made in 11 (8.3%) and 64 (48.5%) patients, respectively. Cyanotic CHD, non-left systemic ventricle, multiple surgeries before menarche, and high central venous pressure (CVP) during puberty (≥13 ​mmHg) were associated with AOM (p ​
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