Latin American Consensus for the Evaluation and Treatment of Patients With Metastatic/Locally Advanced Urothelial Carcinoma

Autor: Ray Manneh Kopp, Fernando Galanternik, Fabio A. Schutz, Fabio Kater, Allan Ramos-Esquivel, Silvia Neciosup, Nora Sobrevilla-Moreno, Laura Bernal Vaca, Linda Ibatá-Bernal, Susan Martínez-Rojas, Maria T. Bourlon
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: JCO Global Oncology, Vol , Iss 10 (2024)
Druh dokumentu: article
ISSN: 2687-8941
DOI: 10.1200/GO.23.00244
Popis: PURPOSEUrothelial cancer accounts for approximately 3% of new cancer cases worldwide, with a high burden of disease in countries with medium and low human development indexes where its incidence and mortality are increasing. The purpose of this consensus is to develop statements on the evaluation and treatment of locally advanced and metastatic urothelial carcinoma that would further guide the clinical practice in Latin America.METHODSA systematic review of the literature was conducted by an independent team of methodologists. Then, a modified Delphi method was developed with clinical specialists from different Latin American countries.RESULTSForty-two consensus statements, based on evidence, were developed to address the staging, the evaluation (suitability for chemotherapy, risk assessment, and biomarkers), and systemic treatment (first-line and subsequent therapies) of locally advanced or metastatic urothelial carcinoma. The statements made in this consensus are suggested practice recommendations in the Latin American context; however, the importance of a complete and individualized patient evaluation as a guide for therapeutic selection is highlighted. The availability and affordability of support tools for the evaluation of the disease, as well as specific therapies, may limit the application of the best practices suggested.RecommendationsTherapeutic decisions need to be tailored to the context-specific clinical setting and availability of resources. Local research is promoted to improve outcomes for patients with this challenging cancer in Latin America.
Databáze: Directory of Open Access Journals