Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases

Autor:	Kira-Lee Koster, Christina Appenzeller, Arno Lauber, Martin Früh, Sabine Schmid
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	kras-mutated nsclc kras inhibition nsclc with active brain metastases Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Case Reports in Oncology, Vol 15, Iss 2, Pp 720-725 (2022)
Druh dokumentu:	article
ISSN:	1662-6575
DOI:	10.1159/000525341
Popis:	Treatment with sotorasib has shown intracranial complete responses and continued intracranial stabilization in KRAS G12C-mutated non-small-cell lung carcinoma (NSCLC) patients with previously treated, stable brain metastases in a post hoc analysis of the ongoing CodeBreaK 100 trial. We present the case of a patient with KRAS G12C-mutant adenocarcinoma of the lung with active untreated brain metastases with a nearly complete intracranial response only 6 weeks after start of sotorasib illustrating the benefit of sotorasib in patients with active, previously untreated brain metastases in KRAS G12C-mutated NSCLC.
Databáze:	Directory of Open Access Journals
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