| Autor: |
Fernanda Santos Mendes, Marcelo Rizzatti Luizon, Ana Cristina dos Santos Lopes, Daniela Alves Pereira, Fernanda Cristina Gontijo Evangelista, Lara Carvalho Godoi, Luci Maria Dusse, Patrícia Nessralla Alpoim |
| Jazyk: |
English<br />Portuguese |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Revista Brasileira de Ginecologia e Obstetrícia, Vol 46 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
0100-7203 |
| DOI: |
10.61622/rbgo/2024ao19 |
| Popis: |
Abstract Objective: To examine whether the DDAH2 promoter polymorphisms -1415G/A (rs2272592), -1151A/C (rs805304) and -449G/C (rs805305), and their haplotypes, are associated with PE compared with normotensive pregnant women, and whether they affect ADMA levels in these groups. Methods: A total of 208 pregnant women were included in the study and classified as early-onset (N=57) or late-onset PE (N =49), and as normotensive pregnant women (N = 102). Results: Pregnant with early-onset PE carrying the GC and GG genotypes for the DDAH2 -449G/C polymorphism had increased ADMA levels (P=0.01). No association of DDAH2 polymorphisms with PE in single-locus analysis was found. However, the G-C-G haplotype was associated with the risk for late-onset PE. Conclusion: It is suggested that DDAH2 polymorphisms could affect ADMA levels in PE, and that DDAH2 haplotypes may affect the risk for PE. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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