Co-ordinated multidisciplinary intervention to reduce time to successful extubation for children on mechanical ventilation: the SANDWICH cluster stepped-wedge RCT

Autor: Bronagh Blackwood, Kevin P Morris, Joanne Jordan, Lisa McIlmurray, Ashley Agus, Roisin Boyle, Mike Clarke, Christina Easter, Richard G Feltbower, Karla Hemming, Duncan Macrae, Clíona McDowell, Margaret Murray, Roger Parslow, Mark J Peters, Glenn Phair, Lyvonne N Tume, Timothy S Walsh, Daniel F McAuley
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Health Technology Assessment, Vol 26, Iss 18 (2022)
Druh dokumentu: article
ISSN: 1366-5278
2046-4924
DOI: 10.3310/TCFX3817
Popis: Background: Daily assessment of patient readiness for liberation from invasive mechanical ventilation can reduce the duration of ventilation. However, there is uncertainty about the effectiveness of this in a paediatric population. Objectives: To determine the effect of a ventilation liberation intervention in critically ill children who are anticipated to have a prolonged duration of mechanical ventilation (primary objective) and in all children (secondary objective). Design: A pragmatic, stepped-wedge, cluster randomised trial with economic and process evaluations. Setting: Paediatric intensive care units in the UK. Participants: Invasively mechanically ventilated children (aged
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