High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia

Autor:	Marina Wierz, Bassam Janji, Guy Berchem, Etienne Moussay, Jerome Paggetti
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	chronic lymphocytic leukemia tumor microenvironment immunotherapy immune-checkpoint blockade mass cytometry Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	OncoImmunology, Vol 7, Iss 8 (2018)
Druh dokumentu:	article
ISSN:	2162-402X 2162402X
DOI:	10.1080/2162402X.2018.1465167
Popis:	In this study, we extensively dissected the phenotypic complexity of the splenic tumor microenvironment (TME) in chronic lymphocytic leukemia (CLL) by high-dimensional mass cytometry (CyTOF). As a result, we identified potential new targets and tested a dual immune checkpoint blockade targeting the TME in pre-clinical mouse models of CLL.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7e7ab01ff8e744ca8d7d61b2d495125c Zobrazit plný text záznamu View record in DOAJ