Synthesis and anaigetical activity of derivatives of 1-indolilethil-3-pirrolin-2-ones

Autor:	N V Dozmorova, V L Gein, N N Kasimova, L I Varkentin, B Ya Syropyatov, N V Danilova
Jazyk:	English<br />Russian
Rok vydání:	2009
Předmět:	триптамин эфиры ацилпировиноградных кислот 3-гидрокси-2 5-дигидропиррол-2-оны анальгетическая активность Medicine
Zdroj:	RUDN Journal of Medicine, Vol 0, Iss 4, Pp 378-380 (2009)
Druh dokumentu:	article
ISSN:	2313-0245 2313-0261
Popis:	Interaction of methyl esters of acylpyruvic acides with mixture of aromatic aldehyde and tryptamine or 5-methoxytryptamine leads to 5-aryl-4-acyl-3-hydroxy-1-[2-(3-indolil)-ethyl)-2,5-dihydropyrrol-2-ones (I). The compounds (I) were transformed to 3,4-diaryl-1,4,5,6-tetrahydro-6-oxo-5-(2-(3-indolil)-ethyl)pyrrolo[3,4-c]pyrazoles (II) by reaction with hydrazine-hydrate. The structure of received compounds is established. The analgetical activity of compounds (I б-е) and (II) is investigated.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7d9905fcf49843d5a50977e9b91282d5 Zobrazit plný text záznamu View record in DOAJ