Catastrophic Antiphospholipid Syndrome
| Autor: | Victoria Bitsadze, Fidan Yakubova, Jamilya Khizroeva, Arina Lazarchuk, Polina Salnikova, Alexander Vorobev, Maria Tretyakova, Natalia Degtyareva, Kristina Grigoreva, Nilufar Gashimova, Margaret Kvaratskheliia, Nataliya Makatsariya, Ekaterina Kudryavtseva, Anna Tomlenova, Jean-Christophe Gris, Ismail Elalamy, Cihan Ay, Alexander Makatsariya |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | International Journal of Molecular Sciences, Vol 25, Iss 1, p 668 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1422-0067 1661-6596 |
| DOI: | 10.3390/ijms25010668 |
| Popis: | Unlike classic APS, CAPS causes multiple microthrombosis due to an increased inflammatory response, known as a “thrombotic storm”. CAPS typically develops after infection, trauma, or surgery and begins with the following symptoms: fever, thrombocytopenia, muscle weakness, visual and cognitive disturbances, abdominal pain, renal failure, and disseminated intravascular coagulation. Although the presence of antiphospholipid antibodies in the blood is one of the diagnostic criteria, the level of these antibodies can fluctuate significantly, which complicates the diagnostic process and can lead to erroneous interpretation of rapidly developing symptoms. Triple therapy is often used to treat CAPS, which includes the use of anticoagulants, plasmapheresis, and high doses of glucocorticosteroids and, in some cases, additional intravenous immunoglobulins. The use of LMWH is recommended as the drug of choice due to its anti-inflammatory and anticoagulant properties. CAPS is a multifactorial disease that requires not only an interdisciplinary approach but also highly qualified medical care, adequate and timely diagnosis, and appropriate prevention in the context of relapse or occurrence of the disease. Improved new clinical protocols and education of medical personnel regarding CAPS can significantly improve the therapeutic approach and reduce mortality rates. |
| Databáze: | Directory of Open Access Journals |
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