| Autor: |
Yuanli LI, Yue HONG, Xiao KONG, Lin LIN, Tianyang ZHANG, Wang LI, Qing LIU, Chunyan GAO, Yuehong LU |
| Jazyk: |
čínština |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Shipin gongye ke-ji, Vol 43, Iss 3, Pp 333-340 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1002-0306 |
| DOI: |
10.13386/j.issn1002-0306.2021050035 |
| Popis: |
To investigate the effects of free phenolics from Lycopus lucidus Turcz. on apoptosis, cell cycle and inflammatory factors in CCl4 induced hepatocyte injury by using a in vitro experiment. Apoptosis and the distribution of cell cycle was analyzed by flow cytometry. The contents of tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8) and the activation of Caspase-3 were measured by kits. The protein expression levels of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6) were also detected by immunohistochemistry. The results showed that compared with the model group, the free phenolics from Lycopus lucidus Turcz. could significantly reduce the apoptosis induced by CCl4 and affect the distribution of cell cycle. In addition, the free phenolics from Lycopus lucidus Turcz. decreased the contents of TNF-α and IL-8 and blocked the activation of Caspase-3 (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
