Advances in research on factors affecting chimeric antigen receptor T‐cell efficacy

Autor:	Delian Zhou, Xiaojian Zhu, Yi Xiao
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	chimeric antigen receptor T‐cell lymphodepletion chemotherapy therapeutic effect Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancer Medicine, Vol 13, Iss 11, Pp n/a-n/a (2024)
Druh dokumentu:	article
ISSN:	2045-7634 63144719
DOI:	10.1002/cam4.7375
Popis:	Abstract Chimeric antigen receptor T‐cell (CAR‐T) therapy is becoming an effective technique for the treatment of patients with relapsed/refractory hematologic malignancies. After analyzing patients with tumor progression and sustained remission after CAR‐T cell therapy, many factors were found to be associated with the efficacy of CAR‐T therapy. This paper reviews the factors affecting the effect of CAR‐T such as tumor characteristics, tumor microenvironment and immune function of patients, CAR‐T cell structure, construction method and in vivo expansion values, lymphodepletion chemotherapy, and previous treatment, and provides a preliminary outlook on the corresponding therapeutic strategies.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7d2b0559f6314471904be29d615c780b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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