Dermal Thickness Increase and Aesthetic Improvement with Hybrid Product Combining Hyaluronic Acid and Calcium Hydroxyapatite: A Clinical and Sonographic Analysis

Autor: Bruna Souza Felix Bravo, MD, Thamires Silva Cavalcante de Almeida, MD, Raquel de Melo Carvalho, MD, Carla Jorge Machado, PhD, MA, Leonardo Gonçalves Bravo, MD, Mariana Calomeni Elias, MD
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Plastic and Reconstructive Surgery, Global Open, Vol 11, Iss 6, p e5055 (2023)
Druh dokumentu: article
ISSN: 2169-7574
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DOI: 10.1097/GOX.0000000000005055
Popis: Background:. Hyaluronic acid filler injections are regarded as the gold standard procedure for facial rejuvenation. Standing as the second most injected cosmetic filler, calcium hydroxyapatite-based fillers are also widely used worldwide. However, to our knowledge, prospective studies assessing patient satisfaction and sonographic changes in dermal thickness after a single session of a hybrid filler combining hyaluronic acid and calcium hydroxyapatite have not been previously published. Methods:. This was a single-center, prospective, quasi-experimental study comprising 15 participants between 32 and 63 years of age. Each participant received a single-session treatment based on facial subcutaneous injections of HArmonyCa, a hybrid combination filler comprising hyaluronic acid and calcium hydroxyapatite. This study involved an intrapatient control design and a 120-day follow-up with clinical and sonographic assessment. For this purpose, standardized photographic images, high-frequency ultrasound evaluations, and physician- and patient-oriented overall aesthetic improvement scores were recorded at 0, 30, 90, and 120 following the procedure. Results:. According to our findings, 20% of the subjects had an exceptional improvement; 20%, “very improved”; and 60%, “improved.” Intrapatient sonographic comparison showed a significant increase in dermal thickness, at 90 and 120 days, only on the side treated (P < 0.001). Conclusion:. In our clinical study, a single-session treatment with a hybrid product combining hyaluronic acid and calcium hydroxyapatite resulted in positive cosmetic satisfaction and increased dermal thickness.
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