Relationship between leukocyte counts and large vessel occlusion in acute ischemic stroke

Autor: Gabor Tarkanyi, Zsofia Nozomi Karadi, Zsofia Szabo, Istvan Szegedi, Laszlo Csiba, Laszlo Szapary
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: BMC Neurology, Vol 20, Iss 1, Pp 1-8 (2020)
Druh dokumentu: article
ISSN: 1471-2377
DOI: 10.1186/s12883-020-02017-3
Popis: Abstract Background Neuroinflammation plays an important role in the pathogenesis of acute ischemic stroke (AIS) and peripheral leukocyte counts have proved to be independent predictors of stroke severity and outcomes. Clinical significance of large vessel occlusion (LVO) in AIS is increasing, as these patients are potential candidates for endovascular thrombectomy and likely to have worse outcomes if not treated urgently. The aim of our study was to assess the relationship between on admission leukocyte counts and the presence of LVO in the early phase of AIS. Methods We have conducted a cross-sectional, observational study based on a registry of consecutive AIS patients admitted up to 4.5 h after stroke onset. Blood samples were taken at admission and leukocyte counts were measured immediately. The presence of LVO was verified based on the computed tomography angiography scan on admission. Results Total white blood cell (WBC) and neutrophil counts were significantly higher in patients with LVO than those without LVO (P
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