| Autor: |
Robert Matongo Persson, Hans Martin Dahl Aguilera, John‐Peder Escobar Kvitting, Ketil Grong, Victorien Emile Prot, Pirjo‐Riitta Salminen, Bård Svenheim, Anita Leiknes, Lodve Stangeland, Rune Haaverstad, Stig Urheim |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Physiological Reports, Vol 11, Iss 7, Pp n/a-n/a (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2051-817X |
| DOI: |
10.14814/phy2.15665 |
| Popis: |
Abstract The purpose of this study was to investigate the effects of loading conditions and left ventricular (LV) contractility on mitral annular dynamics. In 10 anesthetized pigs, eight piezoelectric transducers were implanted equidistantly around the mitral annulus. High‐fidelity catheters measured left ventricular pressures and the slope of the end‐systolic pressure‐volume relationship (Ees) determined LV contractility. Adjustments of pre‐ and afterload were done by constriction of the inferior caval vein and occlusion of the descending aorta. Mitral annulus area indexed to body surface area (MAAi), annular circularity index (ACI), and non‐planarity angle (NPA) were calculated by computational analysis. MAAi was more dynamic in response to loading interventions than ACI and NPA. However, MAAi maximal cyclical reduction (−Δr) and average deformational velocity (−v¯) did not change accordingly (p = 0.31 and p = 0.22). Reduced Ees was associated to attenuation in MAAi‐Δr and MAAi‐v¯ (r2 = 0.744; p = 0.001 and r2 = 0.467; p = 0.029). In conclusion, increased cardiac load and reduced LV contractility may cause deterioration of mitral annular dynamics, likely impairing coaptation and increasing susceptibility to valvular incompetence. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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