| Autor: |
Zheng-jie Huang, Yilin Zhao, Wei-yuan Luo, Jun You, Shui-wen Li, Wen-cheng Yi, Sheng-yu Wang, Jiang-hua Yan, Qi Luo |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
The Scientific World Journal, Vol 2013 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1537-744X |
| DOI: |
10.1155/2013/637086 |
| Popis: |
Purpose. Truncated tissue factor (tTF) fusion protein targeting tumor vasculature can induce tumor vascular thrombosis and necrosis. Here, we generated (RGD)3-tTF in which three arginine-glycine-aspartic (RGD) targeting integrin αvβ3 and tTF induce blood coagulation in tumor vessels. Methods. The bioactivities of (RGD)3-tTF including coagulation activity, FX activation, and binding with integrin αvβ3 were performed. The fluorescent labeled (RGD)3-tTF was intravenously injected into tumor-bearing mice and traced in vivo. The tumor growth, volume, blood vessel thrombosis, tumor necrosis, and survival time of mice treated with (RGD)3-tTF were evaluated. Results. The clotting time and FX activation of (RGD)3-tTF were similar to that of TF (P>0.05) but different with that of RGD (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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