End-condition for solution small angle X-ray scattering measurements by kernel density estimation

Autor: Hiroshi Sekiguchi, Noboru Ohta, Hideaki Ishibashi, Hideitsu Hino, Masaichiro Mizumaki
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Science and Technology of Advanced Materials: Methods, Vol 2, Iss 1, Pp 426-434 (2022)
Druh dokumentu: article
ISSN: 2766-0400
27660400
DOI: 10.1080/27660400.2022.2140021
Popis: We develop a method for calculating the minimum X-ray exposure time for X-ray solution scattering experiments using statistical and mathematical approaches to enhance the measurement efficiency while maintaining data quality. Experts can determine the X-ray exposure time for samples by investigating time-series data of scattering profiles and considering the quality of scattering profiles and the samples’ X-ray damage. In this study, we apply a statistical inequality to estimate the kernel density estimation method’s error to determine the minimum X-ray exposure time for protein solution scattering experiments and evaluate the method’s validity using the results of Guinier analysis as an indicator.
Databáze: Directory of Open Access Journals