New Triterpenoids and Anti-Inflammatory Constituents from Glinus oppositifolius

Autor:	Jih-Jung Chen, Chang-Syun Yang, Yu-Hui Chen, Che-Yi Chao, Yu-Chang Chen, Yeuh-Hsiung Kuo
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Molluginaceae Glinus oppositifolius triterpenoids spergulagenin A spergulagenin B spergulagenin C Organic chemistry QD241-441
Zdroj:	Molecules, Vol 28, Iss 7, p 2903 (2023)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules28072903
Popis:	Three new triterpenoids—spergulagenin B (1), spergulagenin C (2), and spergulagenin D (3)—were isolated from the aerial part of Glinus oppositifolius, along with 17 known compounds (4–20). The structures of these new compounds were identified by spectroscopic and MS analyses. Compounds 3, 5, 19, and 20 were evaluated for inhibition of nitric oxide production in LPS-stimulated RAW 264.7 cells with IC50 values of 17.03, 18.21, 16.30, and 12.64 μM, respectively. Compounds 3, 5, and 20 exhibited inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 cells with IC50 values of 18.35 ± 1.34, 17.56 ± 1.41, and 14.27 ± 1.29 μM, respectively.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c7bece95ac45466e809ed913835a1ff6 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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