Renal metastasis of ovarian granulosa cell tumor

Autor: Kyo Togashi, Tohru Yoneyama, Mihoko Sutoh Yoneyama, Hayato Yamamoto, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Masayuki Futagami, Chikara Ohyama
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: IJU Case Reports, Vol 5, Iss 3, Pp 186-190 (2022)
Druh dokumentu: article
ISSN: 2577-171X
DOI: 10.1002/iju5.12433
Popis: Introduction We would like to present a rare case of metastatic renal tumor. Case presentation A 60‐year‐old woman presented to our department with a left renal tumor. She underwent a total hysterectomy and right adnexal resection for a stage IA ovarian granulosa cell tumor approximately 15 years ago, followed by left adnexal resection and postoperative chemotherapy with gemcitabine and paclitaxel 6 years ago. She received six courses of gemcitabine and carboplatin to treat a stage IC clear cell adenocarcinoma of the ovary. The patient was diagnosed with the left renal tumor and underwent a laparoscopic left nephrectomy. Immunostaining was positive for α‐inhibin and SF‐1 and showed FOXL2 402C→G (C134W) mutation. Finally, the patient was diagnosed with renal metastasis of a granulosa cell tumor. Conclusion To our knowledge, this is a very rare case of renal metastasis of a granulosa cell tumor with the FOXL2 mutation in an adult.
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