Thyroid Function and the Risk of Non-Alcoholic Fatty Liver Disease in Morbid Obesity

Autor: Marta Borges-Canha, João Sérgio Neves, Fernando Mendonça, Maria Manuel Silva, Cláudia Costa, Pedro M. Cabral, Vanessa Guerreiro, Rita Lourenço, Patrícia Meira, Daniela Salazar, Maria João Ferreira, Jorge Pedro, Ana Leite, Madalena Von-Hafe, Catarina Vale, Sara Viana, Ana Sande, Sandra Belo, Eva Lau, Paula Freitas, Davide Carvalho
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Frontiers in Endocrinology, Vol 11 (2020)
Druh dokumentu: article
ISSN: 1664-2392
DOI: 10.3389/fendo.2020.572128
Popis: BackgroundAn association between hypothyroidism and the risk of Non-alcoholic Fatty Liver Disease (NAFLD) has been suggested. This association remains to be elucidated in patients with morbid obesity.AimTo evaluate the association between thyroid function and parameters of liver function and hepatic scores in patients with morbid obesity.MethodsPatients with morbid obesity followed in our center between January 2010 and July 2018 were included. The ones without evaluation of liver and thyroid functions were excluded. Fatty Liver Index (FLI) and BARD scores were used as predictors of hepatic steatosis and fibrosis, respectively.ResultsWe observed a positive association between TSH and both BARD (OR 1.14; p = 0.035) and FLI (OR 1.19; p = 0.010) in the unadjusted analysis. We found a negative association between free triiodothyronine levels and BARD (OR 0.70; p
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