| Popis: |
Major depressive disorder (MDD) with childhood maltreatment is a heterogeneous clinical phenotype of depression with prominent features of brain disconnectivity in areas linked to maltreatment-related emotion processing (e.g., the amygdala). However, static and dynamic alterations of functional connectivity in amygdala subregions have not been investigated in MDD with childhood maltreatment. Here, we explored whether amygdala subregions (i.e., medial amygdala [MeA] and lateral amygdala [LA]) exhibited static functional connectivity (sFC) and dynamic functional connectivity (dFC) disruption, and whether these disruptions were related to childhood maltreatment. We compared sFC and dFC patterns in MDD with childhood maltreatment (n = 48), MDD without childhood maltreatment (n = 30), healthy controls with childhood maltreatment (n = 57), and healthy controls without childhood maltreatment (n = 46). The bilateral MeA and LA were selected as the seeds in the FC analysis. The results revealed a functional connectivity disruption pattern in maltreated MDD patients, characterized by sFC and dFC abnormalities involving the MeA, LA, and theory of mind-related brain areas including the middle occipital area, middle frontal gyrus, superior medial frontal gyrus, angular gyrus, supplementary motor areas, middle temporal gyrus, middle cingulate gyrus, and calcarine gyrus. Significant correlations were detected between impaired dFC patterns and childhood maltreatment. Furthermore, the dFC disruption pattern served as a moderator in the relationship between sexual abuse and depression severity. Our findings revealed neurobiological features of childhood maltreatment, providing new evidence regarding vulnerability to psychiatric disorders. |
